circRNA basic information
circBase ID: -
Name: hsa_circ_CYP24A1
Synonym: circCYP24A1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: TE1, KYSE30, KYSE150, KYSE170
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: PKM2, CCL5
Associated microRNA: -
Biological function: promoted the ability of proliferation, migration, invasion and clone formation, tumor growth
Molecular mechanism: NF-kappaB pathway
Survival: poor
Supported No.:
 1
Description:

Up-regulated circCYP24A1 could activate NF-kB pathway by binding PKM2, which promotes the secretion of CCL5 and accelerate malignant progression of ESCC.
Other information
Title:

circCYP24A1 facilitates esophageal squamous cell carcinoma progression through binding PKM2 to regulate NF-kappaB-induced CCL5 secretion.

Journal: Mol Cancer
Published: 2022/12/14
PubMed ID: 36514094