circRNA basic information
circBase ID: hsa_circ_0008012
Name: -
Synonym: Circ_0008012
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9952
DO name: acute lymphoblastic leukemia
Disease details: acute lymphoblastic leukemia
Species: human
Species details: human
Sample type: cell line
Sample type details: MLL/AF4 ALL cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IKKbeta
Associated microRNA: -
Biological function: regulated cell proliferation and apoptosis
Molecular mechanism: NF-¦ªB pathway
Survival: -
Supported No.:
 1
Description:

We found that circ_0008012 was upregulated in MLL/AF4 ALL cells and regulated cell proliferation and apoptosis. Further computed simulation and RIP showed that IKKbeta was the strongest protein in the NF-¦ªB pathway binding with circ_0008012. As a result, possible regulation of circ_0008012 is suggested by binding IKKbeta in the IKKalpha:IKKbeta:IKKgamma compound, which then phosphorylates I¦ªB and activates NF- ¦ªB:p65:p300 compound in cell nucleus, thereby leading to leukemia.
Other information
Title:

Gene Expression Network and Circ_0008012 Promote Progression in MLL/AF4 Positive Acute Lymphoblastic Leukemia.

Journal: Recent Pat Anticancer Drug Discov
Published: 2022/12/13
PubMed ID: 36503469