circRNA basic information
circBase ID: mmu_circ_0001100
Name: mmu_circ_Snhg11
Synonym: circ-Snhg11
Host Gene: mmu-miR-144-3p
 
 
 
Disease basic information
DO ID:
 9351
DO name: diabetes mellitus
Disease details: diabetic wound healing
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: ECs, HEK293 cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: NFE2L2
Associated microRNA: mmu-miR-144-3p
Biological function: improved EC proliferation, enhanced wound closure, increased the number of capillary-like tube structures
Molecular mechanism: HIF1alpha pathway, miRNA sponge
Survival: better
Supported No.:
 2
Description:

Furthermore, circ-Snhg11-modified ADSC-Exos increased the migratory, proliferative and blood vessel regeneration potential of vascular endothelial cells (ECs). In addition, overexpression (OE) of NFE2L2-HIF1alpha or inhibition of miR-144-3p-both of which are members of the miR-144-3p/NFE2L2/HIF1alpha pathway downstream of circ-Snhg11-reversed the therapeutic effects of circ-Snhg11.
Other information
Title:

Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and accelerate diabetic wound healing.

Journal: Acta Biomater
Published: 2022/12/13
PubMed ID: 36503078