circRNA basic information
circBase ID: -
Name: hsa_circ_SETD3
Synonym: CircSETD3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC827/GR cell line, PC9/GR cell line
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FXR1, ECT2
Associated microRNA: -
Biological function: inhibited cellular apoptosis
Molecular mechanism: -
Survival: -
Supported No.:
 3
Description:

CircSETD3/FXR1/ECT2 axis plays a critical role in the acquired resistance to gefitinib in NSCLC. Our results highlight the potential of circSETD3 as a biomarker and therapeutic target for NSCLC patients with acquired gefitinib resistance.
Other information
Title:

CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.

Journal: Int J Biochem Cell Biol
Published: 2022/12/13
PubMed ID: 36503048