circRNA basic information
circBase ID: -
Name: hsa_circ_Klhl2
Synonym: circKlhl2
Host Gene: hsa-miR-29b-3p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: Acute lung injury
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: microvascular endothelial cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ROCK1
Associated microRNA: hsa-miR-29b-3p
Biological function: Loss of circKlhl2 mitigated lung injury and proinflammatory cytokine expression in sepsis-ALI mice model and alleviated LPS-induced apoptosis and inflammatory response in microvascular endothelial cell (MPVECs) in vitro
Molecular mechanism: The abundances of circKlhl2 and ROCK1 were boosted, while the miR-29b-3p level was diminished in the animal or cell model of sepsis-ALI.
Survival: -
Supported No.:
 1
Description:

CircKlhl2 expedited the sepsis-induced ALI by adjusting miR-29b-3p/ROCK1 axis.
Other information
Title:

Circklhl2 Knockdown Alleviates Sepsis-Induced Acute Lung Injury by Regulating Mir-29b-3p Mediated Rock1 Expression down-Regulation.

Journal: Shock
Published: 2022/12/9
PubMed ID: 36476974