circRNA basic information
circBase ID: -
Name: rno_circ_Kcnk9
Synonym: circKcnk9
Host Gene: rno-miR-124-3p
 
 
 
Disease basic information
DO ID:
 9778
DO name: irritable bowel syndrome
Disease details: Irritable bowel syndrome
Species: rat
Species details: rat
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EZH2
Associated microRNA: rno-miR-124-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 2
Description:

early life stress induces increased expression of circKcnk9 in the CA1 of IBS-like rats. Increased circKcnk9 expression regulates synaptic transmission and enhances LTP, leading to visceral hypersensitivity and anxiety in IBS-like rats. The underlying circKcnk9 signaling pathway is miR124-3p/EZH2. Increased circKcnk9 reinforces its sponging of miR124-3p and strongly suppresses miR124-3p activity, resulting in increased expression of the target gene EZH2.
Other information
Title:

Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome.

Journal: Front Cell Neurosci
Published: 2022/12/6
PubMed ID: 36467610