circRNA basic information
circBase ID: -
Name: hsa_circ_Ralgapa1
Synonym: CircRalgapa1
Host Gene: hsa-miR-873a-5p
 
 
 
Disease basic information
DO ID:
 2560
DO name: morphine dependence
Disease details: morphine tolerance
Species: human
Species details: human
Sample type: PDX
Sample type details: HT22
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: A20
Associated microRNA: hsa-miR-873a-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

chronic morphine administration-mediated down-regulation of circRalgapa1 in the spinal cord contributes to morphine tolerance via miR-873a-5p/A20 axis in mice. Overexpression of circRalgapa1 may be a promising RNA-based therapy for morphine tolerance.
Other information
Title:

CircRalgapa1 facilitates morphine tolerance via miR-873a-5p/A20 axis in mice.

Journal: Neuropharmacology
Published: 2022/12/2
PubMed ID: 36455645