circRNA basic information
circBase ID: -
Name: hsa_circ_LDLR
Synonym: CircLDLR
Host Gene: hsa-miR-667-5p
 
 
 
Disease basic information
DO ID:
 80208
DO name: non-alcoholic fatty liver disease
Disease details: non-alcoholic fatty liver disease
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: Hepa1-6
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SIRT1
Associated microRNA: hsa-miR-667-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircLDLR alleviated the development of NAFLD by inducing autophagic flux while modulating the miR-667-5p/SIRT1 axis reversed its effects, suggesting that targeting circLDLR/miR-667-5p/SIRT1 axis may be a promising therapeutic strategy for NAFLD.
Other information
Title:

CircLDLR acts as a sponge for miR-667-5p to regulate SIRT1 expression in non-alcoholic fatty liver disease.

Journal: Lipids Health Dis
Published: 2022/11/30
PubMed ID: 36443854