circRNA basic information
circBase ID: -
Name: hsa_circ_WDR33
Synonym: circWDR33
Host Gene: hsa-miR-217-5p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: acute lung injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human pulmonary microvascular endothelial cells (HPMECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SERP1
Associated microRNA: hsa-miR-217-5p
Biological function: forced expression of circWDR33 could alleviate LPS-induced inflammatory and apoptotic injury, permeability enhancement and tubule formation arrest in HPMECs.
Molecular mechanism: circWDR33/miR-217-5p/SERP1 formed an axis in HPMECs. MiR-217-5p was highly expressed, while SERP1 was decreased in sepsis-ALI patients and LPS-challenged HPMECs.
Survival: -
Supported No.:
 1
Description:

CircWDR33 protected against LPS-induced inflammatory and apoptotic injury, permeability enhancement and tubule formation arrest in HPMECs via miR-217-5p/SERP1 axis, indicating a new potential therapeutic approach for sepsis-ALI patients.
Other information
Title:

CircWDR33 alleviates human pulmonary microvascular endothelial cell injury in sepsis-associated acute lung injury by targeting miR-217-5p/SERP1 axis.

Journal: Int Immunopharmacol
Published: 2022/11/24
PubMed ID: 36417821