circRNA basic information
circBase ID: hsa_circ_0006916
Name: hsa_circ_HOMER1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3770
DO name: pulmonary fibrosis
Disease details: ulmonary fibrosis
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

knockdown of hsa_circ_0006916 significantly increased the expression levels of M1 molecules IL-1beta and TNF-alpha and reduced the expression level of M2 molecule TGF-beta1, indicating that hsa_circ_0006916 may play an important role in the activation of M1-M2 polarization effect in macrophages.
Other information
Title:

Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.

Journal: Toxicology
Published: 2022/11/21
PubMed ID: 36403901