circRNA basic information
circBase ID: -
Name: hsa_circ_QSOX1
Synonym: circQSOX1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SW620, HCT116, LOVO, HT-29, CT26, MC38
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: poor
Supported No.:
 1
Description:

m(6)A-modified circQSOX1 facilitated CRC tumorigenesis by sponging miR-326 and miR-330-5p to promotes PGAM1 expression, which further promoted CRC immune escape by activating glycolysis and inactivating the anti-CTLA-4 therapy response of CRC.
Other information
Title:

N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells.

Journal: Drug Resist Updat
Published: 2022/11/13
PubMed ID: 36370665