circRNA basic information
circBase ID: -
Name: hsa_circ_Maml2
Synonym: CircMaml2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 77
DO name: gastrointestinal system disease
Disease details: ultiple organ dysfunction syndrome
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: cell proliferation and migration
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

CircMaml2 promotes cell proliferation and migration of MC38 cells and the repair of the intestinal mucosa of mice. This effect is brought about by combining with PTBP1 to improve Ebf1 and interacting with miR-683 to regulate Sec2. Furthermore, PRP8 was discovered to promote the biogenesis of circMaml2.

Other information
Title:

PRP8-Induced CircMaml2 Facilitates the Healing of the Intestinal Mucosa via Recruiting PTBP1 and Regulating Sec62.

Journal: Cells
Published: 2022/11/12
PubMed ID: 36359856