circRNA basic information
circBase ID: -
Name: hsa_circ_UCK2
Synonym: CircUCK2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 6713
DO name: cerebrovascular disease
Disease details: Ischemic stroke
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: mouse brain microvascular endothelial (bEnd.3) cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

circUCK2 upregulates the expression of HECTD1 by combining with FUS and inhibits EndoMT to alleviate BBB damage in IS both in vivo and in vitro.
Other information
Title:

CircUCK2 regulates HECTD1-mediated endothelial-mesenchymal transition inhibition by interacting with FUS and protects the blood-brain barrier in ischemic stroke.

Journal: Kaohsiung J Med Sci
Published: 2022/11/4
PubMed ID: 36326248