circRNA basic information
circBase ID: hsa_circ_0008529
Name: -
Synonym: circ_0008529
Host Gene: hsa-miR-185-5p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: cell line
Sample type details: HK-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SMAD2
Associated microRNA: hsa-miR-185-5p
Biological function: interfering circ_0008529 could attenuate HG-induced effects, and this protection was abated by miR-185 inhibition or SMAD2 re-expression.
Molecular mechanism: circ_0008529 and SMAD2 were competing endogenous RNAs for miR-185-5p via target binding, and circ_0008529 regulated SMAD2 expression via miR-185-5p.
Survival: -
Supported No.:
 2
Description:

Circ_0008529 might be a potential target for DN, which regulated DN progression via miR-185-5p/SMAD2 pathway.
Other information
Title:

Circ_0008529 Contributes to Renal Tubular Cell Dysfunction in High Glucose Stress via miR-185-5p/SMAD2 Pathway in Diabetic Nephropathy.

Journal: Biochem Genet
Published: 2022/11/2
PubMed ID: 36316592