circRNA basic information
circBase ID: -
Name: -
Synonym: CircRNA_45478
Host Gene: mmu-miR-190a-5p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: mouse
Species details: mouse
Sample type: cell line, PDX
Sample type details: BUMPT cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DS
Associated gene: PHLPP1
Associated microRNA: mmu-miR-190a-5p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circRNA_45478 upregulated the expression of Pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase 1 (PHLPP1) via sponging of microRNA (miR)-190a-5p. Finally, inhibition of circRNA_45478 significantly alleviated the progression of ischemic AKI through regulation of the miR-190a-5p/PHLPP1 pathway.
Other information
Title:

CircRNA_45478 promotes ischemic AKI by targeting the miR-190a-5p/PHLPP1 axis.

Journal: FASEB J
Published: 2022/11/1
PubMed ID: 36315192