circRNA basic information
circBase ID: -
Name: hsa_circ_EXOC5
Synonym: circEXOC5
Host Gene: -
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: acute lung injury
Species: human
Species details: human
Sample type: cell line
Sample type details: mouse pulmonary microvascular endothelial cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PTBP1
Associated microRNA: -
Biological function: CircEXOC5 was up-regulated and associated with increased inflammation and activated autophagy in cecal ligation and puncture-induced ALI lung tissues and LPS-challenged MPVECs.
Molecular mechanism: circEXOC5 accelerated_kp2_RNA decay, an E3 ubiquitin ligase for Runx2, and therefore increased Runx2 expression.
Survival: -
Supported No.:
 1
Description:

The signaling cascade circEXOC5/PTBP1/Skp2/Runx2, by essentially regulating inflammation and autophagy in MPVECs, aggravates sepsis-induced ALI.
Other information
Title:

circEXOC5 promotes acute lung injury through the PTBP1/Skp2/Runx2 axis to activate autophagy.

Journal: Life Sci Alliance
Published: 2022/10/28
PubMed ID: 36302650