circRNA basic information
circBase ID: -
Name: mmu_circ_Palm2
Synonym: circPalm2
Host Gene: mmu-miR-129-5p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: acute lung injury
Species: mouse
Species details: mouse
Sample type: cell line
Sample type details: Primary mice pulmonary microvascular endothelial cells (MPVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK1
Associated microRNA: mmu-miR-129-5p
Biological function: Knockdown of circPalm2 attenuated LPS-induced proliferation arrest, apoptosis, and production of proinflammatory cytokine IL-6, IL-beta and TNF-¦Á in MPVECs.
Molecular mechanism: circPalm2 sequestered miR-450b-5p to up-regulate ROCK1 expression, revealing the circPalm2/miR-450b-5p/ROCK1 feedback loop.
Survival: -
Supported No.:
 1
Description:

CircPalm2 knockdown can alleviate LPS-evoked MPVEC apoptosis and inflammation via miR-450b-5p/ROCK1 axis, suggesting the potential involvement of this ceRNA network in sepsis-ALI and a broader approach for the therapy of sepsis-ALI.
Other information
Title:

CircPalm2 knockdown alleviates LPS-evoked pulmonary microvascular endothelial cell apoptosis and inflammation via miR-450b-5p/ROCK1 axis.

Journal: Int Immunopharmacol
Published: 2022/10/18
PubMed ID: 36252478