circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF451
Synonym: circZNF451
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: macrophages polarization
Molecular mechanism: -
Survival: poor
Supported No.:
 1
Description:

Exosomal circZNF451 reshapes the tumor immune microenvironment by inducing macrophages polarization via the FXR1- ELF4-IRF4 axis and is a novel biomarker for predicting the sensitivity of PD1 blockade in LUAD.
Other information
Title:

Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1.

Journal: J Exp Clin Cancer Res
Published: 2022/10/9
PubMed ID: 36209117