circRNA basic information
circBase ID: -
Name: hsa_circ_HOMER1
Synonym: CircHOMER1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HMCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: oxidative stress, inflammation and ECM accumulation
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

CircHOMER1 promoted HG-induced HMCs oxidative stress, inflammation and ECM accumulation via the miR-137/SOX6 axis, suggesting that circHOMER1 might be a target for DN treatment.
Other information
Title:

CircHOMER1 aggravates oxidative stress, inflammation and extracellular matrix deposition in high glucose-induced human mesangial cells.

Journal: Nephrology (Carlton)
Published: 2022/10/2
PubMed ID: 36181383