circRNA basic information
circBase ID: -
Name: hsa_circ_DOCK1
Synonym: -
Host Gene: hsa-miR-196a-5p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: cell line
Sample type details: human OSCC cell lines (CAL-27, SCC-9, SCC-25)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: BIRC3
Associated microRNA: hsa-miR-196a-5p
Biological function: inhibiting cell apoptosis
Molecular mechanism: participate in circDOCK1/miR_196a_5p/BIRC3 axis
Survival: -
Supported No.:
 1
Description:

Our results demonstrated that circDOCK1 regulated BIRC3 expression by functioning as a competing endogenous RNA(ceRNA) and participated in the process of OSCC apoptosis. Thus, we propose that circDOCK1 could represent a novel potential biomarker and therapeutic target of OSCC.
Other information
Title:

CircDOCK1 suppresses cell apoptosis via inhibition of miR_196a_5p by targeting BIRC3 in OSCC.

Journal: Oncol Rep
Published: 2017/12/30
PubMed ID: 29286141