circRNA basic information
circBase ID: -
Name: hsa_circ_UBAP2
Synonym: -
Host Gene: hsa-miR-339-5p, hsa-miR-96-3p, hsa-miR-135b-3p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A549
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK6, cyclin D1, p27 and c-IAP1, Bcl-2, Survivin, Bax, FAK, Rac1 and MMP2, and JNK and ERK1/2
Associated microRNA: hsa-miR-339-5p, hsa-miR-96-3p, hsa-miR-135b-3p
Biological function: promoted proliferation and invasion while inhibits apoptosis
Molecular mechanism: activate JNK and ERK1/2
Survival: -
Supported No.:
 1
Description:

We also found that after circUBAP2 silencing, cell invasion of A549 cells was significantly inhibited. Western blot and Real-time PCR results showed that expression of CDK6, cyclin D1, c-IAP1, Bcl-2, Survivin, FAK, Rac1 and MMP2 were down-regulated, and the expression of p27 and Bax were up-regulated. Moreover, the activities of JNK and ERK1/2 were inhibited because of circUBAP2 silencing, the target genes were miR-339-5p, miR-96-3p and miR-135b-3p.
Other information
Title:

[Effect of Circular RNA UBAP2 Silencing on Proliferation and Invasion of Human Lung Cancer A549 Cells and Its Mechanism].

Journal: Zhongguo Fei Ai Za Zhi
Published: 2017/12/27
PubMed ID: 29277177