circRNA basic information
circBase ID: -
Name: hsa_circ_BCRC4
Synonym: circ_RNA BCRC4
Host Gene: hsa-miR-101
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bladder cancer cell line (UMUC3), normal human urothelial cell line (SV-HUC-1), human metastatic bladder cancer cell line (T24T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-101
Biological function: promoted apoptosis and inhibited viability
Molecular mechanism: up-regulating the expression of hsa-miR-101
Survival: -
Supported No.:
 1
Description:

our findings suggest that BCRC4 functions as a tumor suppressor in BC, and mediates anticancer function, at least in part, by up-regulating the expression of miR-101. Targeting this newly identified circRNA may help us develop a novel strategy for treating human BC.
Other information
Title:

Overexpression of CircRNA BCRC4 regulates cell apoptosis and MicroRNA-101/EZH2 signaling in bladder cancer.

Journal: J Huazhong Univ Sci Technolog Med Sci
Published: 2017/12/23
PubMed ID: 29270748