circRNA basic information
circBase ID: hsa_circ_0086296
Name: -
Synonym: circ_0086296
Host Gene: hsa-miR-576-3p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human umbilical vein endothelial cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: IFIT1
Associated microRNA: hsa-miR-576-3p
Biological function: circ_0086296 expression was significantly upregulated in human carotid artery plaques, oxidized low-density lipoprotein (ox-LDL)-treated HUVECs, and the aorta of atherosclerotic mice.
Molecular mechanism: circ_0086296 sponged miR-576-3p to promote IFIT1-STAT1 expression. Moreover, STAT1 upregulated circ_0086296 expression, forming the circ_0086296/miR-576-3p/IFIT1/STAT1 feedback loop.
Survival: -
Supported No.:
 1
Description:

This study sought to provide a deep understanding of the mechanisms underlying the aberrant EC phenotype in AS.
Other information
Title:

circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p.

Journal: Cell Mol Biol Lett
Published: 2022/9/23
PubMed ID: 36138395