circRNA basic information
circBase ID: -
Name: hsa_circ_GMCL1
Synonym: circGMCL1
Host Gene: hsa-miR-124-3p
 
 
 
Disease basic information
DO ID:
 8778
DO name: Crohn disease
Disease details: Crohn disease
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: ANXA7
Associated microRNA: hsa-miR-124-3p
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circGMCL1 protects intestinal barrier function against Crohns colitis through alleviating NLRP3 inflammasome-mediated epithelial pyroptosis by promoting autophagy through regulating ANXA7 via sponging miR-124-3p.
Other information
Title:

PLGA-microspheres-carried circGMCL1 protects against Crohn colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy.

Journal: Cell Death Dis
Published: 2022/9/11
PubMed ID: 36088391