circRNA basic information
circBase ID: hsa_circ_0001204
Name: -
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 399
DO name: tuberculosis
Disease details: tuberculosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: M.tb-infected macrophages
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: TLR4
Associated microRNA: -
Biological function: Upregulating hsa_circ_0001204 reduced M.tb survival and suppressed the apoptosis and inflammatory response of THP-1 cells.
Molecular mechanism: The TLR4/NF-¦ĘB signalling pathway could be inhibited by hsa_circ_0001204 overexpression, which was activated by M.tb-infection.
Survival: -
Supported No.:
 3
Description:

Hsa_circ_0001204 confers protective effects in M.tb-infected THP-1 cells, at least partly via the inhibition of TLR4/NF-¦ĘB signalling pathway.
Other information
Title:

Hsa_circ_0001204 modulates inflammatory response of macrophages infected by Mycobacterium tuberculosis via TLR4/NF-kappaB signalling pathway.

Journal: Clin Exp Pharmacol Physiol
Published: 2022/9/2
PubMed ID: 36048566