circRNA basic information
circBase ID: hsa_circ_0005045
Name: hsa_circ_RTN4
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3083
DO name: chronic obstructive pulmonary disease
Disease details: chronic obstructive pulmonary disease
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

hsa_circ_0005045 is upregulated by PM(2.5) and binds to the protein cargo peroxiredoxin2, which functionally aggravates hallmarks of COPD by recruiting neutrophil elastase and triggering in situ release of tumor necrosis factor (TNF)-alpha by inflammatory cells.
Other information
Title:

Prediction of COPD acute exacerbation in response to air pollution using exosomal circRNA profile and Machine learning.

Journal: Environ Int
Published: 2022/8/31
PubMed ID: 36041244