circRNA basic information
circBase ID: hsa_circ_0074371
Name: -
Synonym: circ_0074371
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HK2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ELK1
Associated microRNA: hsa-miR-330-5p
Biological function: Silencing circ_0074371 promoted HK2 cells viability and inhibited the HK2 cells apoptosis. miR-330-5p inhibitor weakened circ_0074371 inhibitor-induced cell viability, apoptosis and oxidative stress.
Molecular mechanism: _irc_0074371 acted as a sponge for miR-330-5p to increase ELK1 expression level.
Survival: -
Supported No.:
 1
Description:

Knockdown of circ_0074371 ameliorated LPS-induced HK2 cells apoptosis, inflammation and oxidative stress via regulating miR-330-5p/ELK1, opening a new window into the pathogenesis AKI.
Other information
Title:

Silencing circ_0074371 inhibits the progression of sepsis-induced acute kidney injury by regulating miR-330-5p/ELK1 axis.

Journal: Mamm Genome
Published: 2022/8/23
PubMed ID: 35994105