circRNA basic information
circBase ID: hsa_circ_0004712
Name: -
Synonym: circ_0004712
Host Gene: hsa-miR-633
 
 
 
Disease basic information
DO ID:
 7148
DO name: rheumatoid arthritis
Disease details: Rheumatoid Arthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: RA-FLSs and normal synovial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TRAF6
Associated microRNA: hsa-miR-633
Biological function: Circ_0004712 silencing suppressed the viability, proliferation, migration and inflammatory response and facilitated the apoptosis of RA-FLSs.
Molecular mechanism: miR-633 was confirmed to be a direct target of circ_0004712, and miR-633 knockdown reversed circ_0004712 silencing-mediated protective effects on the dysfunction and inflammation of RA-FLSs. TRAF6 was a direct target of miR-633, and miR-633 overexpression suppressed the aggressive changes of RA-FLSs by down-regulating TRAF6.
Survival: -
Supported No.:
 2
Description:

Circ_0004712 silencing inhibited the aggressive changes of RA-FLSs by targeting miR-633/TRAF6 axis and NF-¦ĘB signaling, which provided new targets for RA therapy.
Other information
Title:

Circ_0004712 Silencing Suppresses the Aggressive Changes of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Targeting miR-633/TRAF6 Axis.

Journal: Biochem Genet
Published: 2022/8/20
PubMed ID: 35984539