circRNA basic information
circBase ID: -
Name: hsa_circ_BIRC6
Synonym: circBIRC6
Host Gene: hsa-miR-543
 
 
 
Disease basic information
DO ID:
 824
DO name: periodontitis
Disease details: periodontitis
Species: human
Species details: human
Sample type: cell line
Sample type details: Periodontal ligament stem cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PI3K
Associated microRNA: hsa-miR-543
Biological function: Downregulation of circBIRC6 enhanced the osteogenic potential of PDLSCs under the inflammatory conditions, and upregulation of circBIRC6 led to opposite findings.
Molecular mechanism: circBIRC6 modulated PDLSC osteogenic differentiation through sponging miR-543. More importantly, we have demonstrated that circBIRC6/miR-543 axis regulated the mineralization capacity of PDLSCs via PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Survival: -
Supported No.:
 1
Description:

In summary, the expression of miR-543 is significantly increased following circBIRC6 downregulation, leading to inhibition of PTEN and subsequently activation of PI3K/AKT/mTOR signaling pathway. Therefore, targeting circBIRC6 might represent a potential therapeutic strategy for improving bone loss in periodontitis.
Other information
Title:

Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.

Journal: Stem Cell Res Ther
Published: 2022/8/14
PubMed ID: 35964136