circRNA basic information
circBase ID: -
Name: hsa_circ_MAP4K2
Synonym: circRNA-MAP4K2
Host Gene: hsa-miR-377
 
 
 
Disease basic information
DO ID:
 8947
DO name: diabetic retinopathy
Disease details: diabetic retinopathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HRVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: VEGFA
Associated microRNA: hsa-miR-377
Biological function: -
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

cMAP4K2 acted as miR-377 sponge to affect the biological activity of miR-377, which led to increased expression of vascular endothelial growth factor A (VEGFA).
Other information
Title:

Targeting circRNA-MAP4K2 for the treatment of diabetes-induced retinal vascular dysfunction.

Journal: Aging (Albany NY)
Published: 2022/8/14
PubMed ID: 35963645