circRNA basic information
circBase ID: -
Name: hsa_circ_ST6GALNAC6
Synonym: CircRNA-ST6GALNAC6
Host Gene: -
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: HSPB1
Associated microRNA: -
Biological function: overexpression of circST6GALNAC6 promoted ferroptosis of bladder cancer cells in vitro and in vivo
Molecular mechanism: P38 MAPK signaling pathway
Survival: -
Supported No.:
 2
Description:

CircST6GALNAC6 inhibits HSPB1 and promotes cell ferroptosis by occupying the phosphorylation site (Ser-15) of HSBP1 and activating the P38 MAPK signaling pathway.
Other information
Title:

CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis.

Journal: Lab Invest
Published: 2022/8/10
PubMed ID: 35945269