circRNA basic information
circBase ID: -
Name: hsa_circ_WDR25
Synonym: circWDR25
Host Gene: hsa-miR-4474-3P
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
DN
Associated gene: ALOX15
Associated microRNA: hsa-miR-4474-3P
Biological function: cell proliferation and invasion
Molecular mechanism: miRNA sponge
Survival: better
Supported No.:
 1
Description:

circWDR25 facilitated HCC cell proliferation and invasion via the circWDR25/miR-4474-3p/ALOX15 and EMT axes and it promoted the expression of CTLA-4 in HSCs and PD-L1 in HCC cells.
Other information
Title:

Hepatic stellate cell exosome-derived circWDR25 promotes the progression of hepatocellular carcinoma via the miRNA-4474-3P-ALOX-15 and EMT axes.

Journal: Biosci Trends
Published: 2022/8/8
PubMed ID: 35934785