circRNA basic information
circBase ID: hsa_circ_0099630
Name: -
Synonym: circ_0099630
Host Gene: hsa-miR-212-5p
 
 
 
Disease basic information
DO ID:
 824
DO name: periodontitis
Disease details: Periodontitis
Species: human
Species details: human
Sample type: cell line
Sample type details: periodontal ligament cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SPRY1
Associated microRNA: hsa-miR-212-5p
Biological function: Overexpression of circ_0099630 repressed iPDLC proliferation and osteogenic differentiation, but circ_0099630 silencing exerted an opposing effect.
Molecular mechanism: circ_0099630 sponged miR-212-5p to block the inhibiting effect of miR-212-5p on SPRY1. Elevated expression of SPRY1 partly reversed the promoting effect of circ_0099630 knockdown on iPDLC proliferation and osteogenic differentiation.
Survival: -
Supported No.:
 3
Description:

Circ_0099630 curbed PDLC proliferation and osteogenic differentiation through elevating SPRY1 expression via sponging miR-212-5p in periodontitis.
Other information
Title:

Circ_0099630 Participates in SPRY1-Mediated Repression in Periodontitis.

Journal: Int Dent J
Published: 2022/8/7
PubMed ID: 35933226