circRNA basic information
circBase ID: hsa_circ_0008529
Name: -
Synonym: circ_0008529
Host Gene: hsa-miR-485-5p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HK-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: WNT2B
Associated microRNA: hsa-miR-485-5p
Biological function: HG largely impaired cell viability and promoted cell apoptosis and inflammation production, while circ_0008529 knockdown attenuated the effects of HG.
Molecular mechanism: Circ_0008529 targeted miR-485-5p, and miR-485-5p inhibition recovered HK-2 cell injury that was blocked by circ_0008529 knockdown.
Survival: -
Supported No.:
 2
Description:

Circ_0008529 targeted the miR-485-5p/WNT2B pathway to regulate HG-induced HK-2 cell apoptosis and inflammatory injury, suggesting that circ_0008529 was a vital regulator in DN development.
Other information
Title:

High Glucose-Induced Human Kidney Cell Apoptosis and Inflammatory Injury Are Alleviated by Circ_0008529 Knockdown via Circ_0008529-Mediated miR-485-5p/WNT2B Signaling.

Journal: Appl Biochem Biotechnol
Published: 2022/8/2
PubMed ID: 35913598