circRNA basic information
circBase ID: hsa_circ_0000064
Name: hsa_circ_B4GALT2
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A549, H1229
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: the protein levels of caspase-3, caspase-9, bax, p21, CDK6 and cyclin D1 significantly restrained by si-hsa_circ_0000064, while the expression of bcl-2 notably increased
Associated microRNA: -
Biological function: promoted proliferation, migration and invasion while inhibits apoptosis
Molecular mechanism: the protein levels of caspase-3, caspase-9, bax, p21, CDK6 and cyclin D1 significantly restrained by si-hsa_circ_0000064, while the expression of bcl-2 notably increased
Survival: poor
Supported No.:
 1
Description:

Western blot analysis showed that the protein levels of caspase-3, caspase-9, bax, p21, CDK6 and cyclin D1 significantly restrained by si-hsa_circ_0000064, while the expression of bcl-2 notably increased in A549 and H1229 cells. Further, si-hsa_circ_0000064 also abated migration and invasion activities of A549 and H1229 cells, which may be associated with reduced expressions of MMP-2 and MMP-9. In general, our data suggest that hsa_circ_0000064 represents a novel potential biomarker and therapeutic target of lung cancer.
Other information
Title:

Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer.

Journal: Biomed Pharmacother
Published: 2017/12/11
PubMed ID: 29223555