circRNA basic information
circBase ID: -
Name: hsa_circ_POLR2A
Synonym: circPOLR2A
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: metastasis
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

circPOLR2A modulated the UBE3C-mediated ubiquitination and degradation of the PEBP1 protein, and further activated the ERK pathway during cRCC progression and metastasis.
Other information
Title:

Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway.

Journal: Mol Cancer
Published: 2022/7/16
PubMed ID: 35840930