circRNA basic information
circBase ID: -
Name: hsa_circ_CCND1
Synonym: circ-CCND1
Host Gene: hsa-miR-138-5p
 
 
 
Disease basic information
DO ID:
 114
DO name: heart disease
Disease details: calcified aortic valve disease
Species: human
Species details: human
Sample type: cell line
Sample type details: AVICs
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: CCND1
Associated microRNA: hsa-miR-138-5p
Biological function: After inhibiting circ-CCND1 expression, a significant reduction was shown in ALP activity, the degree of ossification and the formation of calcium nodules in AVICs
Molecular mechanism: Circ-CCND1/miR-138-5p/CCND1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ-CCND1 sponges miR-138-5p to regulate CCND1 expression.
Other information
Title:

circ-CCND1 regulates the CCND1/P53/P21 pathway through sponging miR-138-5p in valve interstitial cells to aggravate aortic valve calcification.

Journal: J Physiol Biochem
Published: 2022/7/2
PubMed ID: 35776289