circRNA basic information
circBase ID: -
Name: hsa_circ_EXOC6B
Synonym: circEXOC6B
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: chemosensitivity
Molecular mechanism: HIF1A-RRAGB-mTORC1 positive feedback loop.
Survival: better
Supported No.:
 1
Description:

circEXOC6B inhibits the progression of CRC and enhances the chemosensitivity of CRC cells to 5-fluorouracil by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.

Other information
Title:

circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.

Journal: Mol Cancer
Published: 2022/6/24
PubMed ID: 35739524