circRNA basic information
circBase ID: hsa_circ_0060077
Name: -
Synonym: circ_0060077
Host Gene: hsa-miR-145-5p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HK-2 cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: VASN
Associated microRNA: hsa-miR-145-5p
Biological function: Circ_0060077 knockdown ameliorated the inhibitory effect of HG on HK-2 cell proliferation and the promotional effects on cell apoptosis, oxidative stress, inflammation and fibrosis.
Molecular mechanism: MiR-145-5p was identified as the target for circ_0060077 and miR-145-5p inhibition ameliorated the effect of circ_0060077 silencing on HG-induced HK-2 cell injury.
Survival: -
Supported No.:
 1
Description:

Circ_0060077 silencing protected HK-2 cells from HG-induced damage by regulating miR-145-5p/VASN axis.
Other information
Title:

Circ_0060077 Knockdown Alleviates High-Glucose-Induced Cell Apoptosis, Oxidative Stress, Inflammation and Fibrosis in HK-2 Cells via miR-145-5p/VASN Pathway.

Journal: Inflammation
Published: 2022/6/22
PubMed ID: 35729462