circRNA basic information
circBase ID: -
Name: mmu_circ_EXOC5
Synonym: circEXOC5
Host Gene: -
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: acute lung injury
Species: mouse
Species details: mouse
Sample type: cell line, PDX
Sample type details: mouse lung microvascular endothelial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PTBP1/ACSL4
Associated microRNA: -
Biological function: after inhibiting circEXOC5, it improved the lung injury of septic mice. It was confirmed in cell models that ROS levels and ferroptosis in cells were reduced after knocking down circEXOC5.
Molecular mechanism: circEXOC5 had a direct binding relationship with PTBP1.
Survival: -
Supported No.:
 1
Description:

Our study found that the expression of cell ferroptosis and circEXOC5 increased in ALI induced by sepsis, and circEXOC5 aggravated ferroptosis in septic cells by regulating the PTBP1/ACSL4 axis.
Other information
Title:

CircEXOC5 promotes ferroptosis by enhancing ACSL4 mRNA stability via binding to PTBP1 in sepsis-induced acute lung injury.

Journal: Immunobiology
Published: 2022/6/17
PubMed ID: 35709678