circRNA basic information
circBase ID: -
Name: hsa_circ_ZFHX3
Synonym: circZFHX3
Host Gene: hsa-miR-16-5p
 
 
 
Disease basic information
DO ID:
 13743
DO name: spinal cord lipoma
Disease details: Spinal cord injury
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: BV-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: IGF-1
Associated microRNA: hsa-miR-16-5p
Biological function: exosomal circZFHX3 boosted cell viability and repress apoptosis, inflammation, and oxidative stress in LPS-treated BV-2 cells in vitro.
Molecular mechanism: circZFHX3 acted as a sponge of miR-16-5p to regulate IGF-1 expression. Exosomal circZFHX3 reduced cell injury of SCI in vivo.
Survival: -
Supported No.:
 1
Description:

Exosomal circZFHX3 inhibited LPS-induced BV-2 cell injury partly by regulating the miR-16-5p/ IGF-1 axis, hinting at a promising therapeutic strategy for the SCI treatment.
Other information
Title:

Exosomes Secreted from circZFHX3-modified Mesenchymal Stem Cells Repaired Spinal Cord Injury Through mir-16-5p/IGF-1 in Mice.

Journal: Neurochem Res
Published: 2022/6/4
PubMed ID: 35657460