circRNA basic information
circBase ID: -
Name: hsa_circ_SLC8A1
Synonym: CircSLC8A1
Host Gene: hsa-miR-214-5p
 
 
 
Disease basic information
DO ID:
 5844
DO name: myocardial infarction
Disease details: myocardial infarction
Species: human
Species details: human
Sample type: cell line
Sample type details: cardiomyocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TEAD1
Associated microRNA: hsa-miR-214-5p
Biological function: Exosomal circSLC8A1 exacerbated hypoxia-induced repression of cell viability but promotion of cell apoptosis, inflammation, and oxidative stress.
Molecular mechanism: CircSLC8A1 directly targeted miR-214-5p and miR-214-5p downregulation reverted the effects of si-circSLC8A1 on hypoxia-treated cardiomyocytes. TEAD1 was a target of miR-214-5p and circSLC8A1 upregulated TEAD1 level via targeting miR-214-5p.
Survival: -
Supported No.:
 1
Description:

These results suggested that circSLC8A1 aggravated cell damages in hypoxia-treated cardiomyocytes by the regulation of TEAD1 via sponging miR-214-5p.
Other information
Title:

CircSLC8A1 Exacerbates Hypoxia-Induced Myocardial Injury via Interacting with MiR-214-5p to Upregulate TEAD1 Expression.

Journal: Int Heart J
Published: 2022/6/2
PubMed ID: 35650159