circRNA basic information
circBase ID: -
Name: mmu_circ_Pank1
Synonym: circ-Pank1
Host Gene: mmu-miR-7a-5p
 
 
 
Disease basic information
DO ID:
 14330
DO name: Parkinson disease
Disease details: Parkinson disease
Species: mouse
Species details: mouse
Sample type: cell line, PDX
Sample type details: MN9D
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: alpha-syn
Associated microRNA: mmu-miR-7a-5p
Biological function: locomotor dysfunction
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circ-Pank1 is overexpressed in PD and enhances the locomotor dysfunction via the miR-7a-5p/alpha-syn signaling axis.
Other information
Title:

circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/alpha-syn pathway in Parkinson disease.

Journal: Cell Death Dis
Published: 2022/5/20
PubMed ID: 35589691