circRNA basic information
circBase ID: -
Name: hsa_circ_PCBP2
Synonym: CircPCBP2
Host Gene: hsa-miR-33a, hsa-miR-33b
 
 
 
Disease basic information
DO ID:
 0050745
DO name: diffuse large B-cell lymphoma
Disease details: diffuse large B-cell lymphoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human DLBCL cell lines (U2932, OCI-LY3, SU-DHL-3), one normal human lymphoblastoid cell line (GM12878)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PD-L1
Associated microRNA: hsa-miR-33a, hsa-miR-33b
Biological function: cell stemness
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circPCBP2 enhances DLBCL cell stemness but suppresses its sensitivity to CHOP via sponging miR-33a/b to disinhibit PD-L1 expression.
Other information
Title:

CircPCBP2 promotes the stemness and chemoresistance of DLBCL via targeting miR-33a/b to disinhibit PD-L1.

Journal: Cancer Sci
Published: 2022/5/18
PubMed ID: 35579082