circRNA basic information
circBase ID: -
Name: mmu_circ_HIPK3
Synonym: circHIPK3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 6713
DO name: cerebrovascular disease
Disease details: ischemic stroke
Species: mouse
Species details: mouse
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: CDK5R1/SIRT1
Associated microRNA: -
Biological function: apoptosis and mitochondrial dysfunction
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circHIPK3 functions as an endogenous sponge of miR-148b-3p to decrease its activity, resulting in upregulation of CDK5R1 and CDK5 expression, downregulation of SIRT1 expression and subsequent BMEC apoptosis and mitochondrial dysfunction.
Other information
Title:

circHIPK3 regulates apoptosis and mitochondrial dysfunction induced by ischemic stroke in mice by sponging miR-148b-3p via CDK5R1/SIRT1.

Journal: Exp Neurol
Published: 2022/5/17
PubMed ID: 35576990