circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF91
Synonym: circZNF91
Host Gene: hsa-miR-1283
 
 
 
Disease basic information
DO ID:
 1040
DO name: chronic lymphocytic leukemia
Disease details: chronic lymphocytic leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MEC-1, HG-3
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: WEE1
Associated microRNA: hsa-miR-1283
Biological function: Silencing circZNF91 attenuated CLL cell proliferation and induced apoptosis and cell cycle arrest.
Molecular mechanism: circZNF91 could sponge hsa-miR-1283 to suppress its activity, which in turn upregulated WEE1 expression.
Survival: -
Supported No.:
 1
Description:

The circZNF91/miR-1283/WEE1 axis is engaged in the pathological phenotypes of CLL cells, which could serve as potential targets for future therapy development.
Other information
Title:

circZNF91 Promotes the Malignant Phenotype of Chronic Lymphocytic Leukemia Cells by Targeting the miR-1283/WEE1 Axis.

Journal: Biomed Res Int
Published: 2022/5/17
PubMed ID: 35572733