circRNA basic information
circBase ID: -
Name: hsa_circ_Htra1
Synonym: circHtra1
Host Gene: hsa-miR-3960
 
 
 
Disease basic information
DO ID:
 81292
DO name: traumatic brain injury
Disease details: raumatic Brain Injury
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Primary cultures of cortical neurons, astrocytes
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-3960
Biological function: circHtra1 inhibited cell proliferation and promoted apoptosis, and its knockdown reversed these effects.
Molecular mechanism: circHtra1 functions as a hsa-miR-3960 sponge and increases the expression of_RB10, which is involved in NK cell infiltration after TBI.
Survival: -
Supported No.:
 1
Description:

Our results show that circHtra1 promotes neuronal loss by sponging miR-3960 and regulating GRB10 and apoptosis during brain insults. In addition, A-to-I editing could regulate circRNA expression profiles after TBI, and circHtra1 is a potential therapeutic target.
Other information
Title:

circHtra1/miR-3960/GRB10 Axis Promotes Neuronal Loss and Immune Deficiency in Traumatic Brain Injury.

Journal: Oxid Med Cell Longev
Published: 2022/5/17
PubMed ID: 35571247