circRNA basic information
circBase ID: -
Name: hsa_circ_PTP4A2
Synonym: circPTP4A2-miR-330-5p-PDK2
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 13812
DO name: adhesions of uterus
Disease details: adhesions of uterus
Species: human
Species details: human
Sample type: PDX
Sample type details: HuMSCs
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-330-5p
Biological function: Stabilized the mitochondrial metabolism of HuMSCs.
Molecular mechanism: circPTP4A2 was targeted by hsa-miR-330-5p-PDK2hsa-miR-330-5p was found to inhibit PDK2 expression through the 3 UTR target region.
Survival: -
Supported No.:
 1
Description:

We demonstrated that circPTP4A2 was elevated in HuMSCs-seeded on SF-SIS scaffolds and stabilized the mitochondrial metabolism through miR-330-5p-PDK2 signaling, which contributes to endometrial repair progression. These findings demonstrate that HuMSCs-seeded SF-SIS scaffolds have potential for the treatment of IUA.
Other information
Title:

circPTP4A2-miR-330-5p-PDK2 Signaling Facilitates In Vivo Survival of HuMSCs on SF-SIS Scaffolds and Improves the Repair of Damaged Endometrium.

Journal: Oxid Med Cell Longev
Published: 2022/5/17
PubMed ID: 35571241