circRNA basic information
circBase ID: hsa_circ_0007022
Name: -
Synonym: Circ-0007022
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: 293T cells, human ESCC cell lines (Kyse30, Kyse150, Kyse410, Kyse450, Kyse510, TE1)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-338-3p
Biological function: circ-0007022 overexpression activated Epithelial-to-mesenchymal transition and PI3K/Akt pathway, and NRP1 knock-down could reversed this phenomenon.
Molecular mechanism: circ-0007022 could sponge hsa-miR-338-3p and upregulate downstream target of hsa-miR-338-3p, neuropilin-1 (NRP1).
Survival: -
Supported No.:
 1
Description:

Taken together, the circ-0007022/miR-338-3p/NRP1 axis enhances the radiation resistance of ESCC cells_ia_egulating EMT and PI3K/Akt pathway. The new circRNA circ-0007022 is thus expected to be a therapeutic target for ESCC patients.
Other information
Title:

A Circ-0007022/miR-338-3p/Neuropilin-1 Axis Reduces the Radiosensitivity of Esophageal Squamous Cell Carcinoma by Activating Epithelial-To-Mesenchymal Transition and PI3K/AKT Pathway.

Journal: Front Genet
Published: 2022/5/17
PubMed ID: 35571014