circRNA basic information
circBase ID: hsa_circ_0129047
Name: -
Synonym: circ_0129047
Host Gene: hsa-miR-1206
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human bronchial epithelial cell line (Beas-2B), LAC cell lines (A549, Calu-3, H1975, H460, PC9)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1206
Biological function: circ_0129047 or BMPR2 knockdown facilitated the viability, proliferation, adhesion, migration, and invasion, while inhibiting the apoptosis of LAC cells.
Molecular mechanism: circ_0129047 could sponge hsa-miR-1206, and hsa-miR-1206 could directly target BMPR2.
Survival: -
Supported No.:
 2
Description:

In conclusion, circ _0129047 was found to play a tumor suppressive role in LAC progression; it upregulated BMPR2 expression to inhibit LAC progression by sponging miR-1206..
Other information
Title:

Circular RNA (circ)_0129047 upregulates bone morphogenetic protein receptor type 2 expression to inhibit lung adenocarcinoma progression by sponging microRNA (miR)-1206.

Journal: Bioengineered
Published: 2022/5/17
PubMed ID: 35570745